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Breast Cancer Index is the only validated tool to help with patient selection for extended endocrine therapy in ER+ early stage breast cancer. Learn more! E-cadherin loss explains the histopathologic appearance of LCIS including a diffuse growth pattern of this non-gland-forming tumor with discohesive tumor cells. However, the practical application of E-cadherin expression in breast cancer as a prognostic and diagnostic cancer biomarker remains controversial. Biomarkers can also provide information about the prognosis of a cancer (prognostic biomarker), as well as whether a cancer will respond to certain therapies (predictive biomarker). A surgical procedure in which a surgeon removes the breast tissue of both breasts. Non-cancerous. Biomarker breast cancer
of Hospitals, Mumbai, India. Biomarker breast cancer
College and K. Hospital, Parel, Mumbai, India. E-cadherin is expressed in most normal epithelial tissues. Selective loss of E-cadherin can cause dedifferentiation and invasiveness in human carcinomas, leading E-cadherin to be classified as a tumor suppressor. Loss of E-cadherin has been demonstrated in invasive lobular carcinoma of the breast, but the relationship between E-cadherin expression and breast cancer histopathology and prognosis is less clear.